PREVIOUS AWARDS

MEDICAL RESEARCH

 

The following research programmes have been supported with grants approved for winners of the Sir Jules Thorn Award for Biomedical Research and the Sir Jules Thorn PhD Scholarship Programme:

2016
The Sir Jules Thorn Award for Biomedical Research
 (26 preliminary applications):
"Maximizing the health benefits obtained from bariatric surgery"
University College London
Centre for Obesity Research
Professor Rachel Batterham

2015
The Sir Jules Thorn Award for Biomedical Research (21 preliminary applications):
"Myocardial fibrosis and left ventricular decompensation in patients with aortic stenosis"
University of Edinburgh
Centre for Cardiovascular Science
Dr Marc Dweck

The Sir Jules Thorn PhD Scholarship Programme:
• University of Aberdeen
• University of Leicester

2014
The Sir Jules Thorn Award for Biomedical Research (24 preliminary applications):
"Stem Cell Therapy for treatment of congenital heart disease: mending the youngest heart"
University of Bristol
Bristol Royal Hospital for Children
Professor Massimo Caputo

The Sir Jules Thorn PhD Scholarship Programme:
• University of Manchester
• University of Sheffield

2013
The Sir Jules Thorn Award for Biomedical Research (17 preliminary applications):
"Development of interleukin-2 for the treatment of type 1 diabetes"
University of Cambridge
Cambridge Institute for Medical Research
Dr Frank Waldron-Lynch and others

The Sir Jules Thorn PhD Scholarship Programme:
• University of Glasgow
• University of Nottingham

2012
The Sir Jules Thorn Award for Biomedical Research (18 preliminary applications):
"Bringing next generation sequencing to the next generation : early diagnosis of inherited immune deficiency"
Newcastle University
Institute of Cellular Medicine
Professor Sophie Hambleton and others

The Sir Jules Thorn PhD Scholarship Programme:
• University of Dundee
• University of Liverpool
• University of Southampton

2011
The Sir Jules Thorn Award for Biomedical Research:
"Development of a high throughput discovery programme for druggable pathways in Crohn's disease"
University of Oxford
Weatherall Institute of Molecular Medicine
Professor Alison Simmons and others

Please click here to view an interview with Professor Simmons regarding her work.

Selection of publications arising from the 2011 Sir Jules Thorn Award for Biomedical Research:
• Immunity (September 2013) - The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release (also published in European PubMed Central)
• The Journal of Immunology (June 2014) - RNA and imidazoqinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signalling events (also published in European PubMed Central)

The Sir Jules Thorn PhD Scholarship Programme:
• Queen's University Belfast
• University of Birmingham
• University of Leeds

2010
The Sir Jules Thorn Award for Biomedical Research: 
"Vascular stem cell therapy for ischaemic retinopathies"
Queen's University, Belfast
Professor Alan W Stitt

Selection of publications arising from the 2010 Sir Jules Thorn Award for Biomedical Research:

  • Molecular Medicine (September 2011) - Myeloid angiogenic cells act as alternative M2 macrophages and modulate angiogenesis through interleukin-8 (also published in PubMed Central).
  • Stem Cells (Dayton Ohio) (August 2013) - Ex-vivo expansion of human outgrowth endothelial cells leads to il-8-mediated replicative senescence and impaired vasoreparative function (also published in PubMed Central).
  • Progress in retinal and eye research (September 2012) - Bone marrow-cns connections: implications in the pathogenesis of diabetic retinopathy (also published in PubMed Central).

The Sir Jules Thorn PhD Scholarship Programme:
• Cardiff University
• University of Newcastle

2009
The Sir Jules Thorn Award for Biomedical Research: 
"An international resource for the autozygosity mapping and identification of recessive disease genes in consanguineous families"
University of Leeds
Leeds Institute of Molecular Medicine
Professor Colin A Johnson and others

Selection of publications arising from the 2009 Sir Jules Thorn Award for Biomedical Research:
• Nature Genetics (May 2010) - Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes (also published in PubMed Central).
• Journal of Medical Genetics (2010) - GeneScreen: a program for high-throughput mutation detection in DNA sequence electropherograms (also published in the US National Library of Medicine).
• Nucleic Acids Research, Volume 39, Issue 1 (October 2010) - MethylViewer: computational analysis and editing for bisulfite sequencing and methyltransferase accessibility protocol for individual templates (MAPit) projects.

The Sir Jules Thorn PhD Scholarship Programme:
• University of Oxford
• University of Edinburgh
• King's College London

2008
The Sir Jules Thorn Award for Biomedical Research:
No award made

The Sir Jules Thorn PhD Scholarship Programme (2008 was the first year for this programme):
• University of Cambridge
• Imperial College London
• University College London

2007
The Sir Jules Thorn Award for Biomedical Research: 
"Stem cell therapy for liver cirrhosis"
University of Edinburgh
Centre for Inflammation Research
Professor Stuart J Forbes and others

Selection of publications arising from the 2007 Sir Jules Thorn Award for Biomedical Research:

2006
The Sir Jules Thorn Award for Biomedical Research:
"Predicting and preventing adolescent depression"
Cardiff University
Department of Psychological Medicine
Professor Anita Thapar and others

Selection of publications arising from the 2006 Sir Jules Thorn Award for Biomedical Research:

2005
The Sir Jules Thorn Award for Biomedical Research: 
"Non-invasive detection of disease processes in the CNS through the development of advanced magnetic resonance techniques and a statistical neuro-imaging model of the normal brain"
University of Newcastle
School of Clinical and Laboratory Sciences
Professor Andrew Blamire and others

Selection of publications arising from the 2005 Sir Jules Thorn Award for Biomedical Research:

2004
The Sir Jules Thorn Award for Biomedical Research:
"Regulatory T cells and the prevention of Type 1 Diabetes"
University of Bristol
Integrative Neuroscience and Endocrinology
Professor Colin M Dayan and others

Selection of publications arising from the 2004 Sir Jules Thorn Award for Biomedical Research:

  • Diabetologia Volume 53, Number 7 (2010) - Interferon gamma and Interleukin-10 islet-antigen specific T cell responses in autoantibody negative first-degree relatives of subjects with type 1 diabetes.
  • Trends in Endocrinology & Metabolism Volume 19, Issue 8 (September 2008) - Regulatory T cells in Autoimmune Endocrine Diseases.

2003
The Sir Jules Thorn Award for Biomedical Research: 
"Acute infective lung injury : towards cell therapy with anti protease-transfected monocytes"
University of Edinburgh
Centre for Inflammation Research
Professor John Simpson
(See our case study)

Selection of publications arising from the 2003 Sir Jules Thorn Award for Biomedical Research:

2002
The Sir Jules Thorn Award for Biomedical Research: 
"Inflammation in ischaemic brain damage"
University of Manchester
School of Biological Sciences
Professor Dame Nancy Rothwell and others

Selection of publications arising from the 2002 Sir Jules Thorn Award for Biomedical Research:

  • British Journal of Neurosurgery Volume 21, Number 1 (2007) - The reproducibility of transcranial Doppler middle cerebral artery velocity measurements: Implications for clinical practice.
  • European Radiology, Volume 19, Number 4 (2009) - Potential surrogate markers of cerebral microvascular angiopathy in asymptomatic subjects at risk of stroke.
  • Cerebrovascular Diseases, Volume 27, Number 3 (2009) - Classification of Minor Stroke: Intra- and Inter-Observer Reliability.
  • Journal of Neurology, Neurosurgery and Psychiatry, Volume 79, Issue 1 (2008) - Prognosis in patients with transient ischaemic attack (TIA) and minor stroke attending TIA services in the North West of England: The NORTHSTAR Study.
  • British Journal of Clinical Pharmacology Volume 65, Issue 3 (2008) - Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage.
  • Journal of Cerebral Blood Flow & Metabolism (2008) - Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations.

2001
The Sir Jules Thorn Award for Biomedical Research: 
"Gene therapy for X-linked retinitis pigmentosa (X_LRP)"
University College, London
Institute of Opthalmology and Institute of Child Health
Professor Robin Ali and Professor Adrian Thrasher
(See our case study)

Selection of publications arising from the 2001 Sir Jules Thorn Award for Biomedical Research:

  • The New England Journal of Medicine (May 2008) - Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis.
  • Investigative Opthalmology & Visual Science, Volume 46, Number 9 (September 2005) - Gene Replacement Therapy Rescues Photoreceptor Degeneration in a Murine Model of Leber Congenital Amaurosis Lacking RPGRIP.
  • Gene Therapy, Volume 10 (May 2003) - Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration.
  • Molecular Therapy, Volume 10, Number 8 (August 2003) - AAV-Mediated Gene Transfer Slows Photoreceptor Loss in the RCS Rat Model of Retinitis Pigmentosa.
  • The Journal of Gene Medicine, Volume 5 , Issue 9 (September 2003) - Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy.